The main translational output of the CRE will be the Endgame report. We understand that ending RHD does not mean it will be eradicated nor that substantial change to the burden of disease will occur over the life of the CRE. Instead, we are committed to identifying a set of costed, stepwise interventions which are most likely to reduce the incidence of ARF and the prevalence of RHD for Indigenous Australians to the same level as non-Indigenous Australians. Our research agenda and activities will focus on developing these recommendations in an Endgame Report in 2020. This document is already being conceptualized and will be a living document driving our CRE activities until the final report is produced. It will be the core document used in translating our findings into health gain in Australia.